Lorbriqua (Lorlatinib)

Lorbriqua, also known as Lorlatinib, is a targeted therapy used in the treatment of certain types of lung cancer. Specifically, it is designed for patients with anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) who have previously received one or more ALK inhibitors. This medication works by inhibiting the activity of the ALK protein, which is crucial for the growth and spread of cancer cells.

Key highlights of Lorbriqua include:

• Targeted Action: Lorbriqua selectively targets and inhibits ALK, which helps to disrupt the signaling pathways that promote cancer cell growth.


• Indications: It is primarily prescribed for patients with ALK-positive NSCLC, particularly those who have experienced disease progression after prior treatments.


• Administration: Lorbriqua is taken orally, allowing for convenient home administration, which can improve patient adherence to the treatment regimen.


• Clinical Efficacy: Clinical trials have shown that Lorbriqua is effective in shrinking tumors and improving progression-free survival compared to standard therapies.


• Side Effects: Patients may experience side effects including fatigue, elevated cholesterol levels, and potential neurological effects. Regular monitoring is essential to manage these risks.


• Personalized Medicine: Lorbriqua is a part of the growing field of precision medicine, where treatments are tailored based on the genetic makeup of the cancer.


• Research and Development: Ongoing studies continue to explore the full potential of Lorbriqua in various cancer settings and combinations with other therapies.

Overall, Lorbriqua represents a significant advancement in the management of ALK-positive NSCLC, offering hope to patients who have limited treatment options and emphasizing the importance of personalized approaches in cancer therapy.

• Lorlatinib


• Inactive ingredients:




• Microcrystalline cellulose


• Hydroxypropyl cellulose


• Magnesium stearate


• Silicon dioxide


• Polyvinyl alcohol


• Talcon


• Iron oxide


• Other excipients

Lorbriqua (Lorlatinib) is a medication prescribed for the treatment of certain types of cancer, particularly non-small cell lung cancer (NSCLC) that has specific genetic mutations. To use Lorbriqua effectively, follow these detailed instructions:

1. Consult Your Doctor: Before starting Lorbriqua, have a thorough discussion with your healthcare provider. Ensure that you understand the benefits and potential side effects of the medication.


2. Dosage Instructions: Take Lorbriqua exactly as prescribed by your doctor. Typically, it is taken once daily, with or without food. Do not alter the dose without consulting your healthcare provider.


3. Swallow Whole: Take the tablet whole with a glass of water. Do not crush, chew, or split the tablet, as this can affect how the medication works.


4. Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.


5. Monitoring: Regular follow-up appointments with your healthcare provider are essential to monitor your response to the medication and manage any side effects.


6. Potential Side Effects: Be aware of possible side effects, which may include fatigue, nausea, diarrhea, and changes in appetite. Report any severe or concerning symptoms to your doctor immediately.


7. Avoid Certain Medications: Inform your doctor about all other medications you are taking, as some may interact negatively with Lorbriqua. This includes over-the-counter drugs and herbal supplements.


8. Storage: Store Lorbriqua at room temperature, away from moisture and heat. Keep it out of reach of children and pets.


9. Emergency Situations: In case of an overdose or severe allergic reaction, seek immediate medical attention. Have a plan in place for emergencies.


10. Adherence: Maintain a consistent schedule for taking Lorbriqua to maximize its effectiveness. Set reminders if necessary to help you remember.

By following these guidelines, you can ensure the safe and effective use of Lorbriqua as part of your cancer treatment plan. Always prioritize open communication with your healthcare team for the best outcomes.