Entresto (Sacubitril/Valsartan)

Entresto, a combination medication containing Sacubitril and Valsartan, is primarily used in the treatment of heart failure. This innovative drug works by enhancing the body's natural ability to regulate blood pressure and fluid balance, ultimately improving heart function.

Here are some key highlights about Entresto:

• Mechanism of Action: Sacubitril inhibits neprilysin, an enzyme that breaks down natriuretic peptides, while Valsartan is an angiotensin receptor blocker (ARB) that helps lower blood pressure. Together, they promote vasodilation and reduce fluid retention.


• Indications: Entresto is indicated for the management of chronic heart failure with reduced ejection fraction (HFrEF) to decrease the risk of cardiovascular death and hospitalization for heart failure.


• Clinical Benefits: Clinical trials have demonstrated that Entresto significantly reduces the risk of hospitalization and improves overall survival rates in patients with heart failure compared to standard therapies.


• Dosing: The recommended starting dose is typically 49/51 mg twice daily, with adjustments made based on individual patient tolerance and response.


• Side Effects: Common side effects may include hypotension, hyperkalemia, and renal impairment. Patients should be monitored regularly to ensure safety and efficacy.


• Contraindications: Entresto should not be used in patients with a history of angioedema related to previous ACE inhibitor or ARB therapy, or in conjunction with ACE inhibitors.


• Patient Considerations: It's essential for patients to discuss their complete medical history with their healthcare provider, including any other medications they are taking, to avoid potential drug interactions.


• Overall Impact: By effectively managing heart failure symptoms, Entresto enhances the quality of life for many patients, allowing them to engage in daily activities with greater ease.

Always consult with a healthcare professional for personalized medical advice and to determine if Entresto is the right choice for your heart failure management.

• Sacubitril


• Valsartan


• Microcrystalline cellulose


• Silicon dioxide


• Magnesium stearate


• Hypromellose


• Triacetin


• Iron oxide red


• Iron oxide yellow

Entresto (Sacubitril/Valsartan) is a prescription medication used to treat heart failure. It is essential to use this medication exactly as prescribed by your healthcare provider. Follow the instructions below to ensure proper usage.

1. 
   

   Take Entresto by mouth. It can be taken with or without food. However, try to take it at the same time each day to maintain an even level of the medication in your bloodstream.

   
   


2. 
   

   Swallow the tablets whole with a glass of water. Do not crush, chew, or split the tablets, as this may affect how the medication is absorbed in your body.

   
   


3. 
   

   Your doctor will determine the appropriate dosage based on your medical condition and response to treatment. Do not adjust the dose or stop taking Entresto without consulting your healthcare provider.

   
   


4. 
   

   It is important to keep track of your blood pressure and heart rate regularly while using this medication. Your doctor may request periodic monitoring to ensure the medication is working effectively.

   
   


5. 
   

   If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.

   
   


6. 
   

   Inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements, as some may interact with Entresto.

   
   


7. 
   

   If you experience any side effects such as dizziness, lightheadedness, or persistent cough, contact your healthcare provider for guidance.

   
   


8. 
   

   Store Entresto at room temperature, away from moisture and heat, and keep it out of reach of children.

   
   

Always consult your healthcare provider for personalized advice and to address any concerns you may have regarding your treatment with Entresto.