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COSMEGEN INJECTION 0.5mg/1ml vial (Dactinomycin)
$67.74
Active Ingredient : Dactinomycin
COSMEGEN INJECTION 0.5mg/1ml vial (Dactinomycin) is an effective treatment for various cancers, providing essential support in chemotherapy regimens to help combat tumor growth and improve patient outcomes.
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Dispensing Country : India
COSMEGEN INJECTION 0.5mg/1ml vial contains Dactinomycin, a potent antineoplastic antibiotic used primarily in the treatment of various cancers. It works by interfering with RNA and protein synthesis, effectively inhibiting the growth of cancer cells. This medication is commonly prescribed for Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma, and gestational trophoblastic neoplasia.
Each vial of COSMEGEN is formulated as a sterile, lyophilized powder that must be reconstituted before administration. The standard dosage is 0.5mg per 1ml, and it is administered intravenously under strict medical supervision due to its high toxicity. Proper handling and disposal protocols must be followed to minimize risks to healthcare providers.
- Indications: Primarily used for pediatric cancers and certain adult malignancies, including testicular cancer and Kaposi's sarcoma.
- Mechanism of Action: Binds to DNA and inhibits transcription, leading to cell death in rapidly dividing cancer cells.
- Administration: Given via IV infusion, often as part of combination chemotherapy regimens.
- Side Effects: May include bone marrow suppression, nausea, vomiting, hair loss, and increased risk of infections. Extravasation can cause severe tissue damage.
- Precautions: Contraindicated in patients with recent chickenpox or herpes zoster infections. Requires regular monitoring of blood counts and liver function.
Due to its potential for severe side effects, COSMEGEN should only be administered by healthcare professionals experienced in cancer chemotherapy. Patients must be closely monitored for signs of toxicity, including myelosuppression and hepatotoxicity. The drug is light-sensitive and should be stored in its original packaging at controlled room temperature.
This medication is not recommended for pregnant women, as it may cause harm to the fetus. Effective contraception is advised for both men and women during treatment. Patients should be informed about the risks and benefits before starting therapy, and supportive care measures should be in place to manage adverse reactions.
- Dactinomycin 0.5 mg
- Mannitol
- Hydrochloric Acid (for pH adjustment)
- Sodium Hydroxide (for pH adjustment)
- Water for Injection
COSMEGEN INJECTION 0.5mg/1ml vial (Dactinomycin) is a potent antineoplastic medication used primarily to treat certain types of cancer, including Wilms' tumor, rhabdomyosarcoma, and Ewing's sarcoma. It should only be administered under the supervision of a qualified healthcare professional experienced in cancer chemotherapy.
- Preparation:
- Ensure proper aseptic technique is followed during preparation and administration.
- Reconstitute the lyophilized powder with 1.1 mL of sterile water for injection to achieve a concentration of 0.5 mg/mL.
- Gently swirl the vial until the powder is completely dissolved. Do not shake vigorously.
- Inspect the solution for particulate matter or discoloration before use. Discard if any abnormalities are observed.
- Administration:
- Administer via intravenous (IV) injection or infusion, as directed by the physician.
- For IV push, inject slowly over a few minutes to minimize the risk of extravasation.
- For IV infusion, further dilute the reconstituted solution in 0.9% sodium chloride or 5% dextrose and administer over 10-15 minutes.
- Avoid extravasation, as Dactinomycin is a vesicant and can cause severe tissue damage.
- Dosage:
- The dosage varies based on the patient's body surface area, condition, and treatment protocol.
- Typical doses range from 0.015 mg/kg/day to 0.5 mg/m²/day for 5 days, repeated every 3-6 weeks.
- Always follow the prescribing physician's instructions and protocol-specific guidelines.
- Monitoring:
- Monitor blood counts, liver function, and renal function regularly during treatment.
- Observe for signs of infection, bleeding, or severe toxicity, such as mucositis or myelosuppression.
- Hydrate the patient adequately to reduce the risk of tumor lysis syndrome.
- Storage:
- Store the unopened vial at controlled room temperature (20-25°C) and protect from light.
- Once reconstituted, use immediately or store in the refrigerator (2-8°C) for up to 24 hours.
- Discard any unused portion after the recommended storage period.
Patients should be informed about potential side effects, including nausea, vomiting, hair loss, and increased susceptibility to infections. Emergency equipment and medications should be readily available in case of hypersensitivity reactions or extravasation. Always adhere to institutional policies and chemotherapy safety guidelines.
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