Sybrava Pre-Filled Solution for Injection (Inclisiran)

Sybrava Pre-Filled Solution for Injection (Inclisiran) is a groundbreaking treatment designed to lower cholesterol levels in adults with atherosclerotic cardiovascular disease or familial hypercholesterolemia. This medication belongs to a new class of drugs known as small interfering RNA (siRNA) therapies, which work by targeting and silencing the production of PCSK9, a protein that plays a significant role in cholesterol metabolism.

Key highlights of Sybrava include:

• Mechanism of Action: By inhibiting PCSK9, Sybrava effectively increases the liver's ability to remove LDL cholesterol from the bloodstream, leading to significant reductions in cholesterol levels.


• Administration: Offered in a convenient pre-filled injection solution, Sybrava is easy to administer, allowing for self-injection or administration by a healthcare professional.


• Dosing Schedule: The treatment is typically administered as a subcutaneous injection, with a recommended dosing schedule of once every six months after an initial loading dose.


• Clinical Efficacy: Clinical trials have demonstrated that Sybrava significantly reduces LDL cholesterol levels, providing a new option for patients who have not achieved their cholesterol goals with statins or other therapies.


• Tolerability: The safety profile of Sybrava has been well established, with most side effects being mild to moderate, including injection site reactions.


• Patient Support: Sybrava is accompanied by comprehensive patient support programs that offer resources and guidance for patients throughout their treatment journey.

This innovative therapy represents a significant advancement in the management of high cholesterol, providing hope for individuals at high risk of cardiovascular events. Always consult with a healthcare provider to determine if Sybrava is the right choice for your cholesterol management plan.

• Inclisiran


• Sodium chloride


• Disodium phosphate dodecahydrate


• Sodium phosphate dibasic heptahydrate


• Water for injection


• Hydrochloric acid (for pH adjustment)


• Sodium hydroxide (for pH adjustment)

Before using Sybrava Pre-Filled Solution for Injection (Inclisiran), ensure that you have read the patient information leaflet provided with the medication. Follow these instructions carefully to ensure proper administration.

1. Gather Supplies: Collect the pre-filled syringe, alcohol swabs, and a sharps disposal container. Ensure you have a clean, flat surface to work on.


2. Wash Your Hands: Thoroughly wash your hands with soap and water. Dry them completely before handling the syringe.


3. Prepare the Injection Site: Choose an injection site. The recommended sites are the thigh, abdomen, or outer upper arm. Clean the area with an alcohol swab and let it dry completely.


4. Remove the Syringe Cap: Take the pre-filled syringe out of its packaging. Carefully remove the cap from the needle without touching the needle itself. Do not attempt to recap the needle.


5. Hold the Syringe: Hold the syringe firmly with one hand, ensuring that the needle is pointing downwards.


6. Pinch the Skin: Using your other hand, pinch the skin around the injection site to create a fold. This helps to ensure that the medication is delivered into the fatty tissue.


7. Inject the Medication: Insert the needle into the pinched skin at a 90-degree angle. Push the plunger down slowly and steadily until all the medication is injected.


8. Withdraw the Needle: Once the injection is complete, withdraw the needle quickly and apply gentle pressure to the injection site with a clean cotton ball or gauze.


9. Dispose of the Syringe: Immediately place the used syringe in a sharps disposal container. Do not throw the syringe in the regular trash.


10. Wash Your Hands Again: After disposing of the syringe, wash your hands thoroughly with soap and water.

If you experience any pain, swelling, or redness at the injection site, or if you have any questions or concerns regarding the medication, contact your healthcare provider for further assistance. It is essential to follow your prescribed schedule for injections to achieve the best therapeutic outcome.