Prolia, Xgeva (Denosumab) 60mg/ml x 1 Single prefilled syringe (Denosumab 60mg/ml Injection)

Prolia and Xgeva are brand names for the medication denosumab, which is available in a single prefilled syringe containing 60mg/ml of the active ingredient. This medication is primarily used to treat conditions related to bone health, particularly in patients with osteoporosis or those undergoing cancer treatment that may affect bone density.

Denosumab works by inhibiting the activity of osteoclasts, the cells responsible for bone resorption. By doing so, it helps to maintain or increase bone mass and strength, reducing the risk of fractures. This is particularly crucial for individuals who may be at higher risk due to age, hormonal changes, or specific medical conditions.

Key highlights of Prolia and Xgeva include:

• Administered via subcutaneous injection, making it easy to use in outpatient settings.


• Typically given once every six months for Prolia and once every four weeks for Xgeva, depending on the condition being treated.


• Clinically proven to reduce the incidence of fractures in patients with osteoporosis.


• May be used to prevent skeletal-related events in patients with bone metastases from solid tumors.


• Comes with a risk of potential side effects, including hypocalcemia and skin reactions, necessitating monitoring by healthcare professionals.

Overall, denosumab is an effective option for managing bone health in vulnerable populations, offering both convenience and efficacy in treatment.

• Denosumab 60 mg/ml


• Water for injection


• Sodium chloride


• Acetic acid


• Sodium acetate


• Polysorbate 20

Prolia (Denosumab) is a medication used to treat osteoporosis and other conditions related to bone density. It is administered via subcutaneous injection. Follow these detailed instructions for proper use of the Prolia prefilled syringe:

1. Preparation:
   
   
   
   • Wash your hands thoroughly with soap and water before handling the syringe.
   
   
   • Remove the syringe from the refrigerator and allow it to reach room temperature for about 30 minutes. Do not heat or microwave the syringe.
   
   
   
   


2. Inspect the Syringe:
   
   
   
   • Check the syringe for any discoloration or particles. The solution should be clear to slightly opalescent and colorless to pale yellow.
   
   
   • If the solution appears cloudy, discolored, or has visible particles, do not use the syringe and contact your healthcare provider.
   
   
   
   


3. Choose the Injection Site:
   
   
   
   • The injection can be given in the thigh, abdomen, or upper arm. Rotate the injection site with each use to avoid irritation.
   
   
   • Clean the chosen area with an alcohol swab and let it dry completely before injecting.
   
   
   
   


4. Administering the Injection:
   
   
   
   • Remove the cap from the needle, being careful not to touch the needle itself.
   
   
   • Hold the syringe in your dominant hand like a pencil, and with your other hand, pinch the skin at the injection site to create a fold.
   
   
   • Insert the needle at a 90-degree angle to the skin in a quick motion.
   
   
   • Push the plunger down steadily until all the medication is injected.
   
   
   • After the injection, withdraw the needle quickly and apply gentle pressure to the injection site with a cotton ball or gauze.
   
   
   
   


5. Disposal:
   
   
   
   • Immediately dispose of the used syringe in a sharps container. Do not throw it in the household trash.
   
   
   • Follow local regulations for the disposal of medical waste.
   
   
   
   


6. Post-Injection Care:
   
   
   
   • Monitor the injection site for any redness, swelling, or pain. If any severe reactions occur, contact your healthcare provider.
   
   
   • Keep a record of your injection dates and sites to ensure proper rotation.
   
   
   
   

Always follow the instructions provided by your healthcare provider and consult them if you have any questions or concerns regarding the use of Prolia.