Prolia or Xgeva (Denosumab) 60mg/ml x 1 Single prefilled syringe (Denosumab)

Denosumab, available as Prolia or Xgeva, is a medication designed for the treatment and prevention of bone-related conditions. This product comes in a single prefilled syringe containing 60mg/ml of Denosumab, providing a convenient and ready-to-use option for healthcare professionals.

Here are some key highlights of Denosumab:

• Mechanism of Action: Denosumab is a monoclonal antibody that inhibits RANKL (receptor activator of nuclear factor kappa-Β ligand), a crucial factor in the formation, function, and survival of osteoclasts, the cells responsible for bone resorption.


• Indications: Prolia is primarily used for the treatment of osteoporosis in postmenopausal women and for increasing bone mass in men at high risk of fractures. Xgeva is indicated for the prevention of skeletal-related events in patients with bone metastases from solid tumors.


• Administration: The prefilled syringe allows for easy and sterile subcutaneous administration. It is typically administered once every six months for Prolia and once every four weeks for Xgeva, depending on the indication.


• Side Effects: Common side effects may include back pain, pain in extremities, high cholesterol levels, and urinary tract infections. Serious side effects can include hypocalcemia and osteonecrosis of the jaw.


• Monitoring: Patients receiving Denosumab should be monitored for signs of hypocalcemia and dental issues, as appropriate dental care is essential prior to starting treatment.


• Storage: The product should be stored in the refrigerator and protected from light. It can be taken out for a short period before administration, but should not be frozen.

Denosumab represents a significant advancement in the management of bone health, offering patients a targeted therapy to reduce the risk of fractures and manage bone-related complications effectively.

• Denosumab


• Water for Injection


• Sodium Chloride


• Hydrochloric Acid


• Sodium Hydroxide


• Polysorbate 20

Before using Prolia or Xgeva (Denosumab), ensure you have read the medication guide provided by your healthcare provider. Always follow their specific instructions regarding dosage and administration.

Here are detailed steps for using the prefilled syringe:

1. Preparation:
   
   
   
   • Wash your hands thoroughly with soap and water.
   
   
   • Gather all necessary supplies, including the prefilled syringe and an alcohol swab.
   
   
   • Find a clean, well-lit area to prepare for the injection.
   
   
   
   


2. Inspect the syringe:
   
   
   
   • Check the expiration date on the syringe and do not use it if it has expired.
   
   
   • Examine the solution in the syringe; it should be clear and colorless. Do not use if it appears cloudy or has particles.
   
   
   
   


3. Prepare the injection site:
   
   
   
   • Select an injection site, typically the thigh or abdomen, avoiding areas with scars, moles, or bruises.
   
   
   • Clean the chosen area with an alcohol swab and let it dry completely.
   
   
   
   


4. Administer the injection:
   
   
   
   • Remove the cap from the syringe without touching the needle.
   
   
   • Hold the syringe like a pencil and pinch the skin at the injection site.
   
   
   • Insert the needle quickly at a 90-degree angle to the skin.
   
   
   • Press the plunger down slowly and steadily to inject the medication.
   
   
   • Once the syringe is empty, pull the needle out at the same angle.
   
   
   
   


5. After the injection:
   
   
   
   • Apply gentle pressure to the injection site with a cotton ball or gauze.
   
   
   • Dispose of the syringe in a sharps container immediately after use.
   
   
   • Wash your hands again after the procedure.
   
   
   
   


6. Follow-up:
   
   
   
   • Monitor for any side effects, such as swelling, redness, or pain at the injection site.
   
   
   • Contact your healthcare provider if you experience any unusual symptoms or have concerns.
   
   
   
   

It is crucial to adhere to the schedule recommended by your healthcare provider for subsequent doses. Regular follow-ups may be necessary to monitor your response to the treatment.